• In conclusion the results of this investigation suggest that

  2024-02-22

  

  In conclusion, the results of this investigation suggest that the involvement of PGE2 in the pathogenesis of pulpal inflammation and repair may be related to its induction of cAMP production. PGE2-induced cAMP production in dental pulp cells is mediated by binding to the EP2 receptor, activation of

• br Concluding remarks ROP is a

  2024-02-22

  

  Concluding remarks ROP is a major cause of childhood blindness in the world. Current pharmacological therapy focus on anti-VEGF strategy, but this strategy is associated with the unintended effects on delayed eye growth and retinal vasculature development of preterm infants. Preclinical studies u

• AR-C155858 It involves complementary and inflammatory

  2024-02-22

  

  It involves complementary and inflammatory system proteins, mast cells, eosinophils, basophils, macrophages, natural killer (NK) cells and cytokines [1]. Innate immunity, not only include cells, but also barriers that defend the organism to the penetration of pathogenic agents [2]. Important mediat

• br Materials and methods br Results

  2024-02-22

  

  Materials and methods Results Discussion Recent studies have highlighted Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused inju

• The activity of an enzyme may be regulated allosterically as

  2024-02-22

  

  The activity of an enzyme may be regulated allosterically as well as transcriptionally. We have consistently studied REMS deprivation (REMSD) associated NA mediated allosteric regulation of Na-K ATPase activity in neurons and glia in vivo and in vitro (Amar and Mallick, 2015; Amar et al., 2016; Bask

• In considering the roles of these enzymes

  2024-02-22

  

  In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty Nanaomycin A synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surpr

• It is well known that neurosteroids such as

  2024-02-22

  

  It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls

• br Antioxidant polymers conjugates Natural antioxidants are

  2024-02-22

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic Pregnenolone Carbonitrile as a natural antioxidant undergoes yellowish coloration as a result of oxidation

• There are no studies documented the role of

  2024-02-21

  

  There are no studies documented the role of RAS in the differentiation of MSCs into IPCs but there are previous studies indicating that Ang II receptors exhibit opposing actions on MSCs differentiation, into other cell types rather than IPCs. The blockade of AT2R was reported to suppress MSCs differ

• Outro grupo de trabalho analisou pares de g meos dinamarques

  2024-02-21

  

  Outro grupo de trabalho analisou 8.503 pares de gêmeos dinamarqueses de meia‐idade (Calmidazolium chloride de cognição comparados com os que não sofreram qualquer intervenção, no entanto os autores consideram a diferença como um efeito de tamanho negligenciável. Na análise intrapares o gêmeo expost

• In this study we designed and synthesized two

  2024-02-21

  

  In this study, we designed and synthesized two ALK PROTACs (degraders), 5 (MS4077) and 6 (MS4078), by linking ceritinib and pomalidomide [45] through two different linkers. Using human ALCL and NSCLC cells, we characterized both compounds in a battery of assays to demonstrate their effects on reduc

• Studies on both TCDD treated mice and AhR null

  2024-02-21

  

  Studies on both TCDD treated mice and AhR null mice have also pointed to a role of AhR in hematopoiesis [65], [66]. Singh et al. showed that AhR is a negative regulator of HSC (hematopoietic stem cell) proliferation, while deletion of AhR leads to spleen enlargement in juvenile and adult mice [67].

• br Experimental procedures br Results

  2024-02-21

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector 2-APB of most of the sympathetic nerve fibers, and the recep

• br Methods br Results br Discussion

  2024-02-21

  

  Methods Results Discussion Adiponectin is naturally expressed and secreted exclusively from adipocytes, and adiponectin levels and its isoforms in circulation have recently been reported to highly associate with human coronary artery disease (CAD) [46], [47], [48], [49], these studies clear

• br ARIs in the prevention of prostate cancer

  2024-02-21

  

  5ARIs in the prevention of prostate cancer Prostate cancer continues to be a leading cause of male deaths worldwide. In 2009, it was estimated there would be 192,280 new cases of prostate cancer with a predicted 27,360 deaths [25]. Because androgens, and specifically DHT, play a large role in bot

14846 records 189/990 page Previous Next First page 上5页 186187188189190 下5页 Last page