• Based on our studies presented above atipamezole can be

  2021-05-14

  

  Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool ym express synthesis as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new char

• Besides the regulation of the stress responses CRF and

  2021-05-14

  

  Besides the regulation of the stress responses, CRF and the urocortins have been implicated in drug addiction (Bruijnzeel and Gold, 2005, Sarnyai et al., 2001). For instance nicotine, the addictive substance of tobacco, can activate the HPA axis, just like any other stressor may do, although its imp

• The aim of the present study was to investigate

  2021-05-14

  

  The aim of the present study was to investigate the participation of CRF1 and CRF2 in the alterations of the dorsal and ventral striatal dopamine release and the vertical and horizontal locomotor activity observed in rats following chronic nicotine treatment and consequent acute withdrawal. In this

• br Diseases which have been

  2021-05-14

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty Liproxstatin-1 derivatives of human insulin bound to HSA have applications in the treatment of diabetes while pacli

• With regards to what might represent a typical baseline ChE

  2021-05-14

  

  With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it cannabinoid receptor should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the cours

• Iris domestica L Goldblatt Mabb

  2021-05-14

  

  Iris domestica (L.) Goldblatt & Mabb. (syn. Belamcanda chinensis L.) DC. (Iridaceae) occurs naturally in South and East Asia. Despite the fact that former monotypic genus Belamcanda has been included in the extended genus Iris, this classification has been questioned (Wilson, 2011; Mavrodiev et al.,

• Previous research has suggested that the

  2021-05-14

  

  Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t

• Berner et al used a meta analysis to

  2021-05-14

  

  Berner et al used a meta-analysis to show that sildenafil resulted in an effect of 9.65-point improvement. Tadalafil could be pooled into an effect of 8.52-point improvement, and vardenafil showed an effect of 7.50-point improvement. In our present studies, 200 mg udenafil resulted in an effect of 8

• Thus the exact mechanisms responsible for progestogen induce

  2021-05-14

  

  Thus, the exact mechanisms responsible for progestogen-induced changes in immune response are not known but the effects are believed to be exerted through receptor-mediated interactions. Since the mPR α is known to be a G protein-coupled receptor in fish, downstream signaling cascades via secondary

• Synthetic progestogens also known as synthetic gestagens syn

  2021-05-14

  

  Synthetic progestogens (also known as ‘synthetic gestagens’, ‘synthetic progestins’ or simply ‘progestins’) are designed to mimic the effects of progesterone (P4) and are the active pharmaceutical ingredient in many contraceptives and hormone replacement therapies. Since most progestins are derived

• br In addition to the classic

  2021-05-14

  

  In addition to the classic nuclear genomic action, estrogens have been found to induce rapid effects occurring within minutes following administration. These effects are mediated through a subpopulation of estrogen receptors associated with the plasma membrane, a process usually termed “membrane-i

• Considering these reports and with the aim

  2021-05-14

  

  Considering these reports, and with the aim of further investigating the mechanism by which the cAMP-Epac/PKA pathway activates eNOS, we have performed imaging experiments evaluating the effect of drugs that increase cAMP or modify its signalling pathways (PKA or Epac activators and inhibitors) on b

• In the present study we first examined the in

  2021-05-14

  

  In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 Calcium Gluceptate in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material an

• br Chondroitin sulfate proteoglycans CSPGs are major compone

  2021-05-14

  

  Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix in cartilage. Each CSPG comprises a single core protein and attached chondroitin sulfate (CS), belonging to the glycosaminoglycan family of sugar chains. CSPGs and CS are involved in numerous biological and

• br Material and methods br Results br Discussion

  2021-05-14

  

  Material and methods Results Discussion A. fumigatus utilizes several virulence factors that facilitate its establishment in human hosts. Among these factors, the best known are hydrolytic enzymes such as proteases and phospholipases, toxins, melanine and catalases that neutralize the react

14848 records 640/990 page Previous Next First page 上5页 636637638639640 下5页 Last page