• In this study the ASTM C and ASTM C test

  2020-12-09

  

  In this study, the ASTM C1260 and ASTM C1567 test methods were followed to conduct the ASR tests. Three mortar bars were prepared using three types of RHA (600-RHA, 150-RHA, and 44-RHA) and CFA. To prepare the mortar bars, the OPC was replaced by each type of RHA for 10% and 20%, respectively by wei

• Even minor alterations in the surfactants

  2020-12-09

  

  Even minor alterations in the surfactants structure could have consequences on their physico-chemical characteristics; mono-RLs have less solubility, stronger surfaces sorb, and stronger cationic metals binding than homologue di-RLs (Zhang et al., 1997). The HPLC separation of RLs structure is base

• p and p which are downstream of pAkt and pERK

  2020-12-09

  

  p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and Valinomycin arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is well known th

• Another milestone in the field is the de novo discovery

  2020-12-09

  

  Another milestone in the field is the de novo discovery of EPAC2 and EPAC1 specific inhibitors through fluorescence-based HTS assays. Due to the excellent EPAC/PKA selectivity of ABT888 , it has been widely applied as a useful chemical probe to discriminate EPAC related signaling pathways and biolo

• ghrelin receptor antagonist Our results indirectly support t

  2020-12-09

  

  Our results indirectly support the combination of resveratrol and hesperatin treatment for PDN, as this induces GLO1 activity in patients (Xue et al., 2016), as well as metformin, an FDA-approved anti-diabetic treatment, which acts as an MG scavenger to reduce MG levels in type 2 diabetic patients (

• PI K Akt eNOS signaling

  2020-12-09

  

  PI3K-Akt-eNOS signaling is long been known as a cell survival pathway in cardiology [8]. Current study has shown that ginsenosides, which is demonstrated to exhibit cardioprotective effect in several aspects, prevented cardiac ischemia/reperfusion injury via upregulation of PI3K and phosphorylations

• acridine orange For most enolases fluoride acts as an

  2020-12-09

  

  For most enolases, fluoride acts as an inhibitor, while Mg2+ is the most important metal activator. In yeast systems, metal cations and fluoride bind to enolase at the active center of the enzyme, forming a complex. The complex blocks the binding of substrates to the enzyme in yeast systems, thereby

• PKA signalling in the nucleus was thought to

  2020-12-09

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the (±)-CPSI 1306 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and

• Hyaluronic acid HA also called hyaluronan is widely

  2020-12-09

  

  Hyaluronic cyp450 inducers (HA), also called hyaluronan is widely distributed in Extra Cellular Matrix of soft connective tissues including skin, umbilical cord and synofial fluid (Hanamura et al., 2008). Hyaluronic acid has a unique ability to hold 6000mL of water in 1mg of HA and plays an importa

• Fmoc-L-Arg(Aloc)2-OH receptor To elucidate whether the impac

  2020-12-09

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer Fmoc-L-Arg(Aloc)2-OH receptor driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggres

• Fmoc-Ile-Wang resin br EBI structure and expression

  2020-12-09

  

  EBI2 structure and expression The gene encoding EBI2 was originally identified together with EBI1 (CCR7) as the most highly upregulated gene in Epstein–Barr virus-infected Burkitt's lymphoma cells [18]. EBI2 belongs to the rhodopsin-like subfamily of seven transmembrane GPCRs [19]. Although it is

• Interestingly our analyses of human PBMCs using a

  2020-12-09

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 cystamine showed homogeneous high expression of EBI2 compared with Th1 cells, which contained a fraction of c

• The LNX ligand of numb protein X or

  2020-12-09

  

  The LNX (ligand of numb protein-X) or PDZRN (PDZ and RING) family of proteins consists of five members (LNX1–LNX5), the first four of which act as E3‐ubiquitin ligases in various roles, as reviewed elsewhere [14]. LNX proteins comprise a RING domain and two to four PDZ (PSD-95, DlgA, ZO-1) domains [

• Here we discuss implications of several major families of

  2020-12-09

  

  Here, we discuss implications of several major families of RING-type E3 ubiquitin ligases (MDM, Cullin, GRAIL, TRAF, TRIM) as targets in inflammation and immunity, and provide insights into potential small molecule interventions to mediate the cellular responses (summarized in Table 1). We briefly c

• alpha adrenergic receptors br Materials and methods br Resul

  2020-12-08

  

  Materials and methods Results Discussion Tuberculosis is caused by the mycobacterium M. tuberculosis, a pathogen able to survive in the hostile conditions through sophisticated defence mechanisms. In an attempt to clarify some aspects of the M. tuberculosis defence mechanisms, we have inves

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