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br Discussion Cytomegalovirus CMV is a herpes virus
2019-11-11
Discussion Cytomegalovirus (CMV) is a herpes virus that causes primary infection in normal hosts and re-activation infection in compromised hosts with impaired CMI, e.g., organ transplants. Following primary infection, which may be severe, CMV becomes latent in lymphocytes. Reactivation may occur
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Plant uptake of P from OA
2019-11-11
Plant uptake of P from OA could also be affected by arbuscular mycorrhizal fungi (AMF). Approximately 80% of terrestrial plant species form symbiotic associations with AMF (Smith and Read, 2010) which can enhance plant P uptake (Facelli and Facelli, 2002, Pearson and Jakobsen, 1993, Tibbett, 2000).
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Prostaglandins PGs in particular PGE and PGF
2019-11-11
Prostaglandins (PGs), in particular PGE2 and PGF2α, play pivotal roles in human parturition by stimulating cervical ripening, myometrial contraction and fetal membrane rupture (Challis et al., 1997). In human pregnancy, the amnion is the principle source of PGE2 (Duchesne et al., 1978). In the amnio
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It has been reported that cAMP also
2019-11-11
It has been reported that cAMP also acts via Epac and Epac to attenuate CREB. However, in human monocytes ONO-AE1-329 (the EP4 receptor agonist used in this study) worked entirely through the cAMP-PKA pathway and not vis Epac [12]. Our data suggests that the cAMP-PKA-CREB pathway predominates for MU
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br Conflict of interest br Acknowledgements We wish
2019-11-11
Conflict of interest Acknowledgements We wish to thank Arantza Pérez (University of the Basque Country) for her technical contribution to this study. This work was supported by grants from the Jesús Gangoiti-Barrera Foundation, Gobierno Vasco (GIC07/84), MEC () and SAIOTEK (SA-2008/00046).
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boc boc Introduction Myclobutanil MCL RS chlorophenyl H
2019-11-11
Introduction Myclobutanil (MCL), (RS)-2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile (Fig. 1), is a broad-spectrum systemic triazole fungicide with protective, eradicative, and curative action (University of Hertfordshire, 2018). It is employed to control pests such as powdery mild
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br Conclusion The role of DNA PK target in DNA
2019-11-11
Conclusion The role of DNA-PK target in DNA DSB repair renders this N-acetyl D-galactosamine mg kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were ap
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Importantly piPolB holds a great promise
2019-11-11
Importantly, piPolB holds a great promise for developing novel biotechnological applications. For instance, in vitro activities of piPolB, namely, strand displacement and faithful, processive DNA polymerization, can be harnessed for efficient primer-independent whole-genome amplification, whereas th
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The absence of the LIG
2019-11-08
The absence of the LIG3 gene in yeasts has prevented the use of genetically tractable lower eukaryotes, such as Saccharomyces cerevisiae and Schizosaccharomyces pombe, as models to gain insights into the cellular functions of and interplay between the DNA ligases encoded by the LIG1, LIG3 and LIG4 g
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The members in apple are similar in number
2019-11-08
The 8 members in apple are similar in number to the 7 in Arabidopsis and the 8 in rice, but fewer than the 10 found in mammalian species. GenBank numbers have also been reported for DGK homologues from tomato (AW035995), maize (AY106320), wheat (BT009326), a Populus cross (BU828590), grape (CB981130
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br Introduction The stroma associated with breast cancer met
2019-11-08
Introduction The stroma associated with breast cancer metastasis consists of extracellular matrix (ECM) proteins, including fibrillar collagens, and a cellular component comprised of mesenchymal stem/multipotent stromal Amiloride HCl (MSCs), vessels, and cells of the immune system (Pein and Oskar
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The study reported here had the primary goal to
2019-11-08
The study reported here had the primary goal to compare the methylation of HPV late genes with methylation of the DAPK promoter, and with histological or cytological diagnoses among high-risk patients that were referred to a colposcopy clinic based on abnormal cervical cytology. Based on the literat
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During the course of our research
2019-11-08
During the course of our research on mGlu PAMs,, the hydroxyacetophenone scaffold was found to possess dual mGlu PAM and CysLT1 antagonism activity, presumably as orthosteric antagonist (). There is currently an increasing interest in drug discovery to explore multitarget drugs or polypharmacology,
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Introduction Cytochrome P CYP A is the most important enzyme
2019-11-08
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The h2 receptor antagonist level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and
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So far few studies have been conducted on
2019-11-08
So far few studies have been conducted on the role of chemokines in patients with PTSD and avoidant personality disorders. Ogłodek et al. [10] in her studies found an increase in the level of the chemokine CCL-5 in patients with avoidant personality disorder and general anxiety disorder (GAD) as com
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